Cognition, or the ability to process and utilize information for social and emotional development, is an essential aspect of human memory. Studies in humans and other primates have shown that cognitive control, while a crucial developmental milestone, is not a single ability but a suite of constructs involving multiple capacities like degrees of self-knowledge and episodic and prospective memories. These, along with focal and directed attention, help attain goals and generate feelings of confidence or uncertainty. In such conditions, nootropics or cognitive enhancers play an essential role in improving cognitive parameters like memory, mental alertness, and other mental facilities.
Image Credit – https://www.jneurosci.org/content/30/45/14987
Buy Waklert Online, is one such nootropic that, since its advent, has worked wonders in improving a healthy person’s cognitive process and improving performance by masking fatigue. Considered to be the generic equivalent of Armodafinil, a potent nootropic considered the primary treatment option for narcolepsy, sleep apnea, and ADHD, Waklert has been proven to work on neurotransmitter signaling and neuronal-structural network to improve learning and memory satisfactorily.
How Waklert Works
Waklert or Armodafinil is the pharmacologically active R-enantiomer of Modafinil, a widely used wake-promoting agent in sleep disorders. While the exact mechanism of action is under study, animal studies have shown the medication to work on the amygdala, cortical regions, and sleep-promoting neurons of the ventrolateral preoptic nucleus to perform its therapeutic functions. Animal studies conducted on Armodafinil derivatives have shown that the medication in low doses enhances the efficiency of prefrontal cortical information processing while dampening reactivity to threatening stimuli in the amygdala of the brain region
In contrast to other psychostimulants, it has a unique neurochemical profile that helps it bind and inhibit the dopamine transporter (DAT) and norepinephrine transporter (NET), resulting in elevated dopamine and norepinephrine levels.
Armodafinil administration has also been shown to decrease γ-aminobutyric acid (GABA) levels and elevate serotonin (5HT) levels, glutamate, orexin, and histamine, possibly secondary to catecholamine effects to exert its cognitive potential.
Waklert and memory
According to Harvard researchers, memory is an important aspect of human cognition; the continued process of information retention in the form of long-term or short-term memory allows individuals to recall and draw upon past events to frame their understanding skills and behavioral skills to the optimal extent.
Consequently, factors like sleep disturbance or changes in the neurotransmitter levels caused by stress, changes in body physiology, or conditions like narcolepsy or sleep apnea impact cognitive and memory parameters.
In such conditions, Waklert’s use can improve episodic secondary memory, i.e., the memory of everyday events like times, location geography, associated emotions, and other contextual information) that can be explicitly stated or conjured and reduce fatigue levels to a moderate extent.
In a 12-week randomized, double-masked study conducted in obstructive sleep apnea patients suffering from excessive sleepiness problems, three hundred and ninety-one patients were included in a survey and administered 150-250 mg Armodafinil /Waklert once daily. Two hundred sixty patients received either Armodafinil or a placebo daily.
Efficacy Assessments in the form following were conducted along with assessing adverse events.
- Epworth Sleepiness Scale
- Cognitive performance battery
- Brief Fatigue Inventory
After 12 weeks, evaluation of the results showed that Armodafinil/ Waklert significantly reduced fatigue and improved the quality of episodic secondary memory with the patient’s ability to engage in daily living. It was well tolerated and did not adversely impact nighttime sleep. Headaches, nausea, and insomnia were the major adverse reactions reported with its use, indicating its safe nature.
Waklert in healthy individuals
In a study conducted on sixty healthy young adult male volunteers, 100 or 200 mg of the medication produced improvement in decision-making tasks and spatial planning tasks with simultaneous improvement in digit a short-term and working memory parameter, visual pattern recognition memory (the ability to test whether a stimulus is novel or familiar), spatial planning and stop-signal reaction time. The performance improvements were complimented by a slowing in latency on three tests.
Subjects reported feeling more alert, attentive, and energetic, indicating improved neuropsychological task performance when using the medication.
Waklert for improved vigilance
Vigilance is an essential aspect of cognition for ensuring adaptation to changing environmental conditions. Researchers have often postulated that from a neurophysiological point of view, tiredness, fatigue, and a decrease in attention/concentration are parameters that, if not taken care of, can produce sleep pressure and ultimately impact the individual’s strategies for survival.
In such conditions, Armodafinil or Waklert has been observed to work on the neurotransmitters to improve alertness parameters and positively impact the quality of tasks of the individuals.
In a study conducted to impact the efficacy of Armodafinil for vigilance, forty-eight U.S naval air traffic controlled students were enrolled in a trial. The subjects were divided into two groups and administered Armodafinil 150 mg or placebo, following which they were evaluated eight to eleven hours post-dose. At 8:00 am, Armodafinil/placebo was administered, and the subjects were instructed to complete a standard day’s work. After their return at 3:45 pm, they were asked to perform psychomotor vigilance work for four hours. The results showed that participants receiving the 150 mg dose of Armodafinil experienced significantly fewer lapses of attention than the control group.
The study concluded that Armodafinil/Waklert has the potential to promote sustained vigilance in areas where fatigue-related performance issues can be highly problematic.
Waklert in immunocompromised patients
In addition to working on cognitive performance in healthy individuals, Waklert use has also shown positive results on the fatigue scales of immunocompromised patients. In a four-week double-blind trial conducted on 70 HIV+ diagnosed patients, the use of Armodafinil, the primary component of Waklert, and the use of the medication improved fatigue levels with the mood of the subjects. Approximately 75% of the enrolled subjects reported a positive response rate on using Armodafinil and reported improved energy levels. While the use of Armodafinil didn’t reduce depressive symptoms in the absence of improved energy, those with Axis I depressive disorder did show a favorable outcome with improved cognitive levels.
Image Credit – https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3142348/
The medication was well tolerated and effective for the majority of the participants. After six months, those subjects still using Armodafinil/Waklert had more energy and fewer depressive symptoms than the people no longer using the drug.
Animal studies and clinical research have shown the importance of Armodafinil, the chief ingredient of Waklert, in improving cognitive parameters safely. Being the generic derivative of Armodafinil, Waklert has equal potential to work on cognition levels and improve work performance, memory, and attention levels. However, you must take care to use the medication as per the physician’s advice to obtain the effects safely. Despite having a safe nature, Armodafinil can cause anaphylactic reactions if you are allergic to the ingredients. To prevent drug-related interactions, it would be best to discuss your allergy history with the physician before using the drug.